Probing multivalency in ligand–receptor-mediated adhesion of soft, biomimetic interfaces

• Stephan Schmidt,
• Hanqing Wang,
• Daniel Pussak,
• Simone Mosca and
• Laura Hartmann

Beilstein J. Org. Chem. 2015, 11, 720–729, doi:10.3762/bjoc.11.82

• and therefore sufficiently high for potential multivalent binding to the binding pockets of ConA (separated by ≈6.5 nm). The absence of a multivalency effect could be explained by the large dissociation rates of mannose–ConA complexes prohibiting chelate or sub-site binding. This is caused by the

• binding assay could lead to different conclusions on multivalency effects. In typical inhibition/competition affinity assays steric shielding is the main contributor to the observed multivalency effect [24][25] in particular for large polymeric scaffolds. In direct binding assays, as conducted here

Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW

• Lisa Maria Henning,
• Sumati Bhatia,
• Miriam Bertazzon,
• Michaela Marczynke,
• Oliver Seitz,
• Rudolf Volkmer,
• Rainer Haag and
• Christian Freund

Beilstein J. Org. Chem. 2015, 11, 701–706, doi:10.3762/bjoc.11.80

• ± 6 μM in solution whereas it was 17 ± 0.016 μM for hPG-peptide conjugate 2, demonstrating an approximately tenfold overall affinity enhancement. However, when considering that ≈7 peptides are bound per nanoparticle, the actual multivalency effect is small. For both the monovalent ligand and the hPG

Synthesis of multivalent carbohydrate mimetics with aminopolyol end groups and their evaluation as L-selectin inhibitors

• Joana Salta,
• Jens Dernedde and
• Hans-Ulrich Reissig

Beilstein J. Org. Chem. 2015, 11, 638–646, doi:10.3762/bjoc.11.72

• multivalency effect is not evident and a sound structure–activity discussion is not feasible as the two compounds have different end groups and different flexibilities. A series of related compounds is required to have a better understanding of structure–property relationships and the influence of multivalency

• multivalency effect and to understand structure–property relationships of compounds of this type. Structures of O-sulfated divalent amide 32 and trivalent amide 34 and their respective IC50 values for L-selectin as determined by SPR. General approach to divalent or trivalent carbohydrate mimetics on the basis

Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation

• Meriem Smadhi,
• Sophie de Bentzmann,
• Anne Imberty,
• Marc Gingras,
• Raoudha Abderrahim and
• Peter G. Goekjian

Beilstein J. Org. Chem. 2014, 10, 1981–1990, doi:10.3762/bjoc.10.206

• good affinity for Pseudomonas aeruginosa lectin lecA. They are convenient biological probes for investigating the roles of lecA and lecB in biofilm formation. Keywords: antibiotic; biofilm; glycocluster; lectin; multivalency effect; multivalent glycosystems; Introduction Pseudomonas aeruginosa (PA

High-affinity multivalent wheat germ agglutinin ligands by one-pot click reaction

• Henning S. G. Beckmann,
• Heiko M. Möller and
• Valentin Wittmann

Beilstein J. Org. Chem. 2012, 8, 819–826, doi:10.3762/bjoc.8.91

• multivalent ligands with disproportionally enhanced avidity. A prerequisite for an effective multivalency effect, however, is that the linking spacer between the individual epitopes has the correct geometry to allow a simultaneous multipoint association, i.e., a chelating binding mode. Wheat germ agglutinin